We Can't Stop

In the spirit of Puddles the Clown's rendition of Royals, this Miley Cyrus cover has a key change at 3:13.  
Also, the background singers are the shit.
-Nick

Go Away Little Girl

I'm sorry but I can't hear this song without thinking he's singing it about Marie.
Either way, still a great tune.
-Trov

The Happening

I always liked this song but never knew the name of it. 

Key change happens when Diana throws her arms up in the air.

-Tony

Opus 17 (Don't You Worry About Me)

Key change shortly after the saxophone solo, then up a half-step up almost every verse after.

-Joe Bruno 

Little GTO

This is the kind of rock and roll I love.  Commonly misattributed to the Beach Boys, this song rocks hard and drops a bomb ass key change after the guitar solo at 1:40. 
-Nick

Hymn

Epic. and one of my favorite key changes at 3:40.
-Emily

Jump (For My Love)

What a classic example of awesomeness. In a time before digital sampling, the Pointer SIster's sing the hook of this song exactly the same every time.  Amazing.  Key change at 3:15, immediately after awesome Dr. J footage. 

-Nick